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Mixed Gonadal Dysgenesis

45,X/46,XY Mosaicism flag

45,X/46,XY Mosaicism, also called Mixed Gonadal Dysgenesis, is a rare intersex variation that affects 1 in 15,000 individuals. It is a chromosomal karotype in which some of one's cells have an X chromosome and some have XY chromosomes. Each case is different depending on the exact location and amount of X cells and XY cells in one's body.

CTM individuals with this variation are typically shorter than usual, have a low output of testosterone, and typically have a micropenis, although they may have a common penis.

CTF individuals with this variation are typically born with vagina aplasia, an enlarged clitoris, and may have only a single vaginal hole that connects to both urinal and sexual output.

Both CTM and CTF individuals with this variation may have ambiguous genitals as well and fertility is common.

One with this variation can have any internal sex organs, though asymmetrical gonads and other structures are common. Depending on how the gonads develop, the output of estrogen and testosterone may vary, however it is common for those with this variation to have a masculine puberty, making CTF individuals with this variation to also have hyperandrogenism.

History & Coining[]

The earliest mention of Mixed Gonadal Dysgenesis appears to have been in 1992 by Richard E. Behrman in the 14th edition of the Nelson textbook of Pediatrics.

Flags & Symbols[]

The flag was created by Mod Hermy of Pride-Color-Schemes on Tumblr on or before June 15, 2017. It has no confirmed meaning.

Resources[]

https://archive.ph/2022.02.11-103018/https://pride-color-schemes.tumblr.com/post/161844110960/45x46xy-mosaicism

https://archive.ph/2022.02.11-103224/https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=1772

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926925/

https://archive.ph/2022.02.11-103457/https://www.cincinnatichildrens.org/health/m/mixed-gonadal-dysgenesis

https://archive.ph/2012.05.30-123442/http://www-personal.umd.umich.edu/~jcthomas/JCTHOMAS/1997%20Case%20Studies/N.Justus.html