49,XXXXY syndrome flag
49,XXXXY Syndrome, also called Fraccaro Syndrome, is an extremely rare intersex variation in AMAB or CTM individuals in which they have three extra X chromosomes. It occurs in approximately 1 out of 85,000-100,000 AMAB individuals. It is considered a variation of Klinefelter Syndrome.
Traits of 49,XXXXY syndrome can vary, but it usually includes learning difficulties/intellectual disabilities, low muscle tone, hypogonadism, delayed growth, dental issues, curved pinky fingers, a variety of birth defects that may affect heart, bones, brain and/or kidneys, and distinctive facial features, such as widely spaced eyes, a flat nasal bridge, and epicanthal folds. Some of these symptoms may classify one as physically disabled.
One common symptom is an undergrown penis and/or undescended testes (crytorchidism). This often causes one not to produce as much testosterone, often leading to a lack of body hair and a lack of many masculine traits, along with breast growth. This may also cause an over production of estrogen, which may cause one to fall under aromatase excess syndrome and/or AMAB Hypogonadism. All of those with this variation are incapable of sperm production and are infertile.
History & Coining[]
This variation was first diagnosed in 1960 and was named Fraccaro syndrome after the individual who researched it.
Flags & Symbols[]
The flag was created by FANDOM user ViralSystem on March 15, 2021. The greens represent facial features, yellow represents the intersex spectrum, light orange represents chromosomal abnormalities, and the other oranges represent the community.
Resources[]
https://archive.ph/2021.10.02-152400/https://en.wikipedia.org/wiki/XXXXY_syndrome
https://archive.ph/2022.02.11-113135/https://medlineplus.gov/genetics/condition/49xxxxy-syndrome/
https://archive.ph/2022.02.11-113428/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426158/