Ablepharon Macrostomia Syndrome (AMS) is a condition that may or may not be considered intersex. Some may consider this a syndrome that causes intersex traits, rather than an intersex trait in of itself. This syndrome is often found to overlap with Fraser syndrome and can affect both CTM and CTF individuals.
Symptoms exclusively found in CTF individuals include labial hypoplasia and absent breasts. A symptom exclusively found in CTM individuals is penile agenesis.
Symptoms that can be found in CTM and CTF individuals include ambiguous genitalia, absent or small nipples, loose and/or thin skin, wrinkled skin, club feet, fused toes, shortened hands, absent or underdeveloped eyelids, absent eyebrows, absent eyelashes, fine hair, small ears, nasal abnormalities, large teeth, lip abnormalities, and underdeveloped cheekbones and/or jawbones. They may also be blind and/or death, or have other sight and/or hearing impairments.
This variation is similar to Barber Say syndrome and Facial Ectodermal Dysplasia.
AMS is caused by mutations in the TWIST2 gene, which is a basic helix-loop-helix transcription that binds specific types of DNA. This mutation affects a highly conserved residue of twist-related protein 2.
Resources[]
https://archive.ph/2022.02.13-075722/https://en.wikipedia.org/wiki/Ablepharon_macrostomia_syndrome